TASK-1 channel blockade by AVE1231 increases vasocontractile responses and BP in 1- to 2-week-old but not adult rats.

Anastasia A ShvetsovaDina K GaynullinaNadine SchmidtPeter BugertElena V LukoshkovaOlga S TarasovaRudolf Schubert

Published in: British journal of pharmacology (2020)

We showed that TASK-1 channels are important for negative feedback regulation of vasocontraction in young but not adult rats. The influence of TASK-1 channels most likely contributes to low BP level at perinatal age.

Keyphrases

pregnant women
childhood cancer
randomized controlled trial
clinical trial
middle aged
study protocol