A Phase III Multicenter Randomized Clinical Trial of 60 Gy versus 50 Gy Radiation Dose in Concurrent Chemoradiotherapy for Inoperable Esophageal Squamous Cell Carcinoma.

Yujin XuBaiqiang DongWeiguo ZhuJiancheng LiRong HuangZongwen SunXinmei YangLiping LiuHan HeZhongxing LiaoNi GuanYue KongWanwei WangJianxiang ChenHuijuan HeGuoqin QiuMing ZengJuan PuWangyuan HuYong BaoZhi-Gang LiuJun MaHao JiangXianghui DuJin HuTingting ZhuangJing CaiJin HuangHua TaoYuan LiuXiaodong LiangJuying ZhouGuangzhou TaoXiao ZhengMing Chen

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

The 60 Gy arm had similar survival endpoints but a higher severe pneumonitis rate compared with the 50 Gy arm. Fifty Gy should be considered as the recommended dose in CCRT for ESCC.

Keyphrases

phase iii
locally advanced
double blind
open label
clinical trial
rectal cancer
early onset
randomized controlled trial
rheumatoid arthritis
placebo controlled
radiation therapy
study protocol
free survival