Hypofractionated versus standard radiation therapy in combination with temozolomide for glioblastoma in the elderly: a meta-analysis.

Victor M LuPanogiotis KerezoudisDesmond A BrownTerry C BurnsAlfredo Quinones-HinojosaKaisorn L Chaichana

Published in: Journal of neuro-oncology (2019)

The combination of hRT + TMZ is feasible in well-selected elderly GBM cases, and appears to confer a statistically comparable PFS compared to sRT + TMZ. However, expectations that the OS with hRT + TMZ is comparable to that of sRT + TMZ in all elderly GBM presentations should be tempered. It is likely a specific subgroup of elderly GBM patients will benefit greatly from the addition of TMZ to hRT, and greater investigation is needed to identify their characteristics.

Keyphrases

radiation therapy
middle aged
community dwelling
newly diagnosed
end stage renal disease
ejection fraction
randomized controlled trial
small cell lung cancer
peritoneal dialysis
patient reported outcomes
locally advanced
open label