Vitamin D May Play a Vital Role in Alleviating Type 2 Diabetes Mellitus by Modulating the Ferroptosis Signaling Pathway.
Qiong-Wen ZhangYan WangZi-Ying TongCui-Ping LiLian-Ping HePublished in: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (2023)
Ferroptosis is an iron-dependent death mode mediated by the aggregation of lipid peroxides and lipid-reactive oxygen species. It is characterized by iron-dependent lipid peroxide accumulation accompanied by oxidoreductase deficiency. Pancreatic beta cell dysfunction and insulin resistance are two major causes of type 2 diabetes mellitus (T2DM). Iron accumulation and metabolism may play a role in the development of T2DM. The molecular mechanism of β cell apoptosis and iron death in T2DM were reviewed. In addition, we discuss recent insights on the relationship between the trace element iron and apoptosis of β cells in T2DM.
Keyphrases
- signaling pathway
- cell death
- iron deficiency
- cell cycle arrest
- glycemic control
- insulin resistance
- induced apoptosis
- reactive oxygen species
- oxidative stress
- type diabetes
- endoplasmic reticulum stress
- pi k akt
- fatty acid
- adipose tissue
- cell proliferation
- heavy metals
- single cell
- high fat diet
- stem cells
- cell therapy
- skeletal muscle
- weight loss
- cardiovascular risk factors