LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice.
Devadoss J SamuvelYasodha KrishnasamyLi LiJohn J LemastersC James ChouZhi ZhongPublished in: RPS pharmacy and pharmacology reports (2023)
This novel HDACi protects against IRI most likely by epigenetic upregulation of antioxidant proteins and post-translational modifications of NFκB thus inhibiting iNOS expression and inflammatory responses.
Keyphrases
- histone deacetylase
- oxidative stress
- poor prognosis
- signaling pathway
- induced apoptosis
- diabetic rats
- ischemia reperfusion injury
- long non coding rna
- dna damage
- dna methylation
- pi k akt
- gene expression
- high fat diet induced
- acute myocardial infarction
- nitric oxide synthase
- cell proliferation
- acute ischemic stroke
- binding protein
- lps induced
- anti inflammatory
- immune response
- adipose tissue
- nuclear factor
- skeletal muscle
- heat shock
- endoplasmic reticulum stress
- left ventricular