A Dietary Mixture of Oxysterols Induces In Vitro Intestinal Inflammation through TLR2/4 Activation: The Protective Effect of Cocoa Bean Shells.

Daniela RossinLetricia Barbosa-Pereira Noemi IaiaGabriella TestaBarbara SotteroGiuseppe PoliGiuseppe ZeppaFiorella Biasi

Published in: Antioxidants (Basel, Switzerland) (2019)

TLR2 and TLR4 mainly contribute to inducing oxysterol-dependent intestinal inflammation. The fractionation method of CBS allowed the recovery of fractions rich in (-)-epicatechin and tannins able to counteract oxysterol-induced inflammation, thus highlighting the beneficial biological potential of specific CBS extracts.

Keyphrases

oxidative stress
toll like receptor
inflammatory response
immune response
diabetic rats
high glucose
endothelial cells