High-frequency Ultrasound Assessment of Systemic Sclerosis Skin Involvement: Intraobserver Repeatability and Relationship With Clinician Assessment and Dermal Collagen Content.
Victoria A FlowerShaney Louise BarrattDarren J HartAmanda B MackenzieJacqueline A ShipleyStephen G WardJohn D PaulingPublished in: The Journal of rheumatology (2020)
Our data demonstrate excellent reproducibility and reassuring convergent validity with dermal collagen content. Detection of subclinical abnormalities is an additional benefit of HFUS. The observed correlations with collagen quantification support further investigation of HFUS as an alternative to mRSS in clinical trial settings.
Keyphrases
- wound healing
- systemic sclerosis
- high frequency
- clinical trial
- interstitial lung disease
- transcranial magnetic stimulation
- tissue engineering
- magnetic resonance imaging
- electronic health record
- randomized controlled trial
- study protocol
- rheumatoid arthritis
- double blind
- phase ii
- ultrasound guided
- quantum dots
- clinical evaluation
- idiopathic pulmonary fibrosis