Targeted literature review of the burden of extraintestinal pathogenic Escherichia Coli among elderly patients in Asia Pacific regions.
Norio OhmagariWon Suk ChoiHung-Jen TangPetar AtanasovXiaobin JiangLuis Hernandez PastorYoshikazu NakayamaJason ChiangKyunghwa LimMaria Carmen NieveraPublished in: Journal of medical economics (2023)
(ExPEC) is a leading cause of invasive disease, including bacteremia and sepsis.A targeted literature review included the most recent data from 34 published studies on the epidemiology and clinical and economic burden of IED in the elderly/high risk populations in China, Japan, South Korea, Taiwan, and Australia.ExPEC accounted for 46.0% (1,238/2,692) of bacteria-related invasive diseases in patients aged above 60 years in South Korea, followed by China (44.4% (284/640)), Taiwan (39.0% (1,244/3,194)), and Japan (18.1% (581/3,206)), while Australia reported ExPEC out of all pathogens (54.7% (4,006/7,330)) in general adults. Studies reported increases in length-of-stay and in-hospital 30-day all-cause between 9% to 12%. These factors along with antimicrobial resistance observed in the elderly call for preventive and curative actions in these regions.Data for costs associated with ExPEC induced BSI or sepsis in this region are limited, but evidence shows increasing expenditures.
Keyphrases
- antimicrobial resistance
- escherichia coli
- case report
- end stage renal disease
- acute kidney injury
- prognostic factors
- intensive care unit
- electronic health record
- cancer therapy
- septic shock
- middle aged
- ejection fraction
- newly diagnosed
- chronic kidney disease
- big data
- gram negative
- risk factors
- case control
- healthcare
- community dwelling
- emergency department
- high glucose
- randomized controlled trial
- patient reported outcomes
- drug induced
- multidrug resistant
- machine learning
- endothelial cells
- adverse drug
- data analysis
- artificial intelligence
- biofilm formation
- meta analyses