Evaluation of CD49f as a novel surface marker to identify functional adipose-derived mesenchymal stem cell subset.

Kangkang ZhaXu LiGuangzhao TianZhen YangZhiqiang SunYu YangFu WeiBo HuangShuangpeng JiangHao LiXiang SuiShuyun LiuQuanyi Guo

Published in: Cell proliferation (2021)

In the current study, the expression of CD49f on ADSCs was identified for the first time. The expression of CD49f on ADSCs was influenced by in vitro culture passage number and inflammatory factor treatment. Compared with unsorted ADSCs, CD49f + ADSCs exhibited superior cellular functions, thus may have great application value in mesenchymal stem cell (MSC)-based therapies.

Keyphrases

mesenchymal stem cells
poor prognosis
bone marrow
oxidative stress
stem cells
umbilical cord
cell therapy