12-lipoxygenase promotes tumor progress by TGF-β1-mediated epithelial to mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.

Yan Qu Zhihua WenSi MiPengxiang ChenJianbo WangYibin JiaYufeng Cheng

Published in: Cancer management and research (2019)

In conclusion, our study proved that 12-LOX/12-HETE-promoted tumor migration and invasion might partly be through TGF-β1-mediated EMT in ESCC, and 12-LOX could be a promising biomarker for predicting prognosis in ESCC patients.

Keyphrases

poor prognosis
long non coding rna
end stage renal disease
transforming growth factor
ejection fraction
newly diagnosed
chronic kidney disease
epithelial mesenchymal transition
prognostic factors
low density lipoprotein
signaling pathway