Silmitasertib, a casein kinase 2 inhibitor, induces massive lipid droplet accumulation and nonapoptotic cell death in head and neck cancer cells.

Ying-Wen Su Wen-Yu Huang Huan-Chau Lin Po-Nien LiaoChing-Yung LinXiang-Yu Lin Sing-Han Huang Yi-Ting Chen Pao-Shu Wu

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2022)

The findings demonstrate that CK2 inhibition impairs normal cellular energy metabolism and may be an attractive therapy for treating aggressive SCCHN.

Keyphrases

cell death
high throughput
single cell
cell cycle arrest
protein kinase
fatty acid