Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies.

Zola Chihombori QuaoMancy TongElena BryceSeth GullerLawrence W ChamleyVikki M Abrahams

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2017)

By aPL inhibiting HEEC chemokine secretion and promoting sFlt-1 release, the uterine endothelium may contribute to impaired placentation and vascular transformation. LMWH and ASA may further contribute to endothelium dysfunction in women with obstetric APS.

Keyphrases

endothelial cells
nitric oxide
low dose
systemic lupus erythematosus
high glucose
pregnant women
venous thromboembolism
signaling pathway
oxidative stress
cardiovascular events
induced pluripotent stem cells
antiplatelet therapy
pluripotent stem cells
growth factor
endometrial cancer
coronary artery disease