Blockade of D3 receptor prevents changes in DAT and D3R expression in the mesolimbic dopaminergic circuit produced by social stress- and cocaine prime-induced reinstatement of cocaine-CPP.
Rocío Guerrero-BautistaAurelio Franco-GarcíaJuana M HidalgoFrancisco Fernández-GómezM Victoria MilanésCristina NuñezPublished in: Journal of psychopharmacology (Oxford, England) (2020)
Our results suggest that the selective D3R antagonist ability to inhibit DAT and D3R up-regulation could represent a possible mechanism for its behavioral effects in cocaine-memories reinstatement induced by social stress.