Developmental decrease in parvalbumin-positive neurons precedes increase in flurothyl-induced seizure susceptibility in the Brd2+/- mouse model of juvenile myoclonic epilepsy.
Emily McCarthyFaariah ShakilPatrick Saint AngeEmily Morris CameronJames MillerShilpa PathakDavid A GreenbergJana VelíškováLibor VelisekPublished in: Epilepsia (2020)
A decrease in striatal PVA+ GABAergic neurons developmentally precedes the onset of increased seizure susceptibility and likely contributes to the expression of the syndrome.