Atf4 protects islet β-cell identity and function under acute glucose-induced stress but promotes β-cell failure in the presence of free fatty acid.

Mahircan YaganSadia NajamRuiying HuYu WangPrasanna DadiYanwen XuAlan J SimmonsRoland SteinChristopher M AdamsDavid A JacobsonKen LauQi LiuGuoqiang Gu

Published in: bioRxiv : the preprint server for biology (2024)

Atf4 is dispensable in β-cells in young miceAtf4 protects β-cells under high glucoseAtf4 exacerbate fatty acid-induced β-cell defectsAtf4 activates translation but depresses lipid-metabolism.

Keyphrases

induced apoptosis
fatty acid
single cell
cell therapy
endoplasmic reticulum stress
cell cycle arrest
transcription factor
stem cells
drug induced
cell death
mesenchymal stem cells
adipose tissue
high glucose
diabetic rats
extracorporeal membrane oxygenation
stress induced
endothelial cells
pi k akt
aortic dissection