Homologous Recombination Deficiency Landscape of Breast Cancers and Real-World Effectiveness of Poly ADP-Ribose Polymerase Inhibitors in Patients With Somatic BRCA1 / 2 , Germline PALB2 , or Homologous Recombination Deficiency Signature.

Felipe Batalini Russell W Madison Ethan S Sokol Dexter X JinKuei-Ting ChenBrennan Decker Dean C Pavlick Garrett M Frampton Gerburg M Wulf Judy E Garber Geoffrey R Oxnard Alexa B Schrock Nadine M Tung

Published in: JCO precision oncology (2023)

represent an additional 19% of mBC that can potentially benefit from PARPi. Randomized trials exploring a more inclusive biomarker such as HRDsig are warranted.

Keyphrases

dna repair
dna damage
randomized controlled trial
replacement therapy
systematic review
copy number
oxidative stress
gene expression
dna methylation
structural basis
smoking cessation