Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis.
Meredyth Grace Llewellyn WilkinsonDale MouldingThomas C R McDonnellMichael OrfordChris WincupJoanna Y J TingGeorg W OttoRestuadi RestuadiDaniel KelbermanCharalampia PapadopoulouSergi CastellanoSimon EatonClaire T DeakinElizabeth C RosserLucy R WedderburnPublished in: Annals of the rheumatic diseases (2022)
These results describe a novel pathway where altered mitochondrial biology in JDM CD14+ monocytes lead to oxmtDNA production and stimulates ISG expression. Targeting this pathway has therapeutical potential in JDM and other IFN type 1-driven autoimmune diseases.
Keyphrases
- mitochondrial dna
- dendritic cells
- copy number
- oxidative stress
- poor prognosis
- immune response
- peripheral blood
- nk cells
- interstitial lung disease
- cancer therapy
- endothelial cells
- gene expression
- disease activity
- human health
- binding protein
- genome wide
- long non coding rna
- risk assessment
- rheumatoid arthritis
- climate change