Identification of a novel prognosis-associated ceRNA network in lung adenocarcinoma via bioinformatics analysis.

Yumiao LiXiaoxue YuYuhao ZhangXiaofang WangLinshan ZhaoDan LiuGuofa ZhaoXiangpeng GaoJiejun FuAimin ZangYou-Chao Jia

Published in: Biomedical engineering online (2021)

ENST00000609697 was abnormally expressed in LUAD. Furthermore, downregulation of ENST00000609697 and its target gene RASL12 was associated with poor prognosis in LUAD. The ENST00000609697-hsa-miR-6791-5p-RASL12 axis may play a tumor-suppressive role. These results suggest new potential prognostic and therapeutic biomarkers for LUAD.

Keyphrases

poor prognosis
bioinformatics analysis
long non coding rna
cell proliferation
copy number
risk assessment
gene expression
genome wide identification
genome wide analysis