Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer's disease.

Jagan A PillaiJames BenaGurkan BebekLynn M BekrisAaron Bonner-JacksonLei KouAkshay PaiLauge SørensenMads NeilsenStephen M RaoMark ChanceBruce T LambJames B Leverenznull null

Published in: Annals of clinical and translational neurology (2020)

Baseline levels of immune cell chemotactic cytokine CCL2 in the CSF and IL-10 pathway dysregulation impact longitudinal cognitive and functional decline in MCI-AD. CCL2's utility appears comparable to biomarkers of neurodegeneration in predicting rapid decline.

Keyphrases

cognitive decline
mild cognitive impairment
liver injury
liver fibrosis
oxidative stress
drug induced
cross sectional
cerebrospinal fluid