Inhibition of Aurora Kinase A by Alisertib Reduces Cell Proliferation and Induces Apoptosis and Autophagy in HuH-6 Human Hepatoblastoma Cells.
Jingyi TanWenfeng XuLei LeiHui LiuHong WangXian CaoMan XuPublished in: OncoTargets and therapy (2020)
High expression of AURKA is a potential predictor of poor prognosis in HB patients. AURKA knockdown reduced the viability of HuH-6 cells, and ALS treatment inhibited cell proliferation and induced apoptosis and autophagy via the p38 MAPK signaling pathway. Our results suggest that AURKA may be a novel therapeutic target and ALS a potential therapeutic drug for the treatment of HB.
Keyphrases
- induced apoptosis
- signaling pathway
- endoplasmic reticulum stress
- poor prognosis
- oxidative stress
- pi k akt
- cell proliferation
- cell cycle arrest
- long non coding rna
- epithelial mesenchymal transition
- end stage renal disease
- cell death
- ejection fraction
- chronic kidney disease
- newly diagnosed
- emergency department
- peritoneal dialysis
- prognostic factors
- amyotrophic lateral sclerosis
- replacement therapy
- tyrosine kinase