Intravenous Tenecteplase vs Alteplase Before Mechanical Thrombectomy in Patients with Large Vessel Occlusion Stroke. A Systematic Review & Meta-analysis.
Mohammed A AlmannaZiad S AlorainiRobert W RegenhardtAdam A DmytriwMohammed A BayounisMohammed A Bin-MahfoozYousef I AlghamdiYsmeen T BucklainAbdulrahman Y AlhoumailyNaif M AlotaibiPublished in: Cerebrovascular diseases (Basel, Switzerland) (2024)
Patients with LVO who received TNK as the primary fibrinolytic agent bridging to MT demonstrated higher rates of pre-MT recanalization, similar rates in post-MT recanalization, and equivalent functional independence outcomes at 90 days compared to those who received ALT. The administration of TNK before MT showed comparable results in the 90-day all-cause mortality rate compared to those who received ALT. These results warrant further trials for TNK to be used as a superior fibrinolytic agent to ALT in LVO-MT candidates.