Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human Aorta.
Elizabeth L ChouMark D ChaffinBridget SimonsonJames Paul PirruccelloAmer-Denis AkkadMahan NekouiChristian L Lino CardenasKenneth C BediCraig NashDejan JuricJames R StoneEric M IsselbacherKenneth B MarguliesCarla KlattenhoffPatrick T EllinorMark E LindsayPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Using nuclear RNA sequencing, we describe the cellular diversity of healthy and aneurysmal human ascending aorta. Sporadic aortic aneurysm is characterized by differential gene expression within known cellular classes rather than by the appearance of novel cellular forms. Single-nuclear RNA sequencing of aortic tissue can be used to prioritize genes at aortic trait loci.
Keyphrases
- aortic valve
- pulmonary artery
- genome wide association study
- aortic dissection
- single cell
- genome wide
- gene expression
- endothelial cells
- left ventricular
- coronary artery
- pulmonary hypertension
- aortic aneurysm
- induced pluripotent stem cells
- pulmonary arterial hypertension
- high resolution
- pluripotent stem cells
- late onset
- heart failure
- amyotrophic lateral sclerosis
- genome wide analysis