Tryptophan and arginine catabolic enzymes and regulatory cytokines in clinically isolated syndrome and multiple sclerosis.
Lilian ChaAnderson P JonesStephanie TrendScott N ByrneMarzena J Fabis-PedriniWilliam M CarrollRobyn M LucasJudith M ColeDavid R BoothAllan G KermodePrue H HartPublished in: Clinical & translational immunology (2018)
Higher IDO and ARG expression in CIS and MS provides one sustained homeostatic mechanism to control MS-associated inflammation. However, potent extrinsic mediators in serum may regulate immune cell function in CIS and associations between IDO, ARG and cytokine expression.