Defects at the Posttranscriptional Level Account for the Low TCRζ Chain Expression Detected in Gastric Cancer Independently of Caspase-3 Activity.

Ana Aguinaga-BarrileroPatricia Castro-SánchezIgnacio JuárezAlberto Gutiérrez-CalvoNoelia Rodríguez-PérezAdela LopezRemedios GómezJose Manuel Martin-Villa

Published in: Journal of immunology research (2020)

These results further place the defect responsible for the low TCRζ expression in cancer at the posttranscriptional level and suggests contrary to what has been proposed in other pathologies that elevated caspase-3 activity is not the causative agent.

Keyphrases

poor prognosis
cell death
regulatory t cells
induced apoptosis
papillary thyroid
binding protein
long non coding rna
squamous cell
oxidative stress
signaling pathway
lymph node metastasis