Caspofungin Suppresses Brain Cell Necroptosis in Ischemic Stroke Rats via Up-Regulation of Pellino3.

Yi-Yue ZhangJing TianZi-Mei PengBin LiuYa-Wei PengXiao-Jie ZhangZhong-Yang HuXiu-Ju LuoJun Peng

Published in: Cardiovascular drugs and therapy (2021)

We conclude that Pellino3 has an important role in counteracting necroptosis via ubiquitination of RIPK1 and caspofungin can suppress the brain cell necroptosis in ischemic stroke through upregulation of Pellino3.

Keyphrases

single cell
resting state
cell therapy
white matter
atrial fibrillation
signaling pathway
functional connectivity
cell proliferation
poor prognosis
cerebral ischemia
multiple sclerosis
blood brain barrier