CircBIRC6 affects prostate cancer progression by regulating miR-574-5p and DNAJB1.

Bin ZhaoJinye YangFengming RanYuanlong ShiLibo YangYuanpeng DuanZhiyu ShiXin LiJianpeng ZhangZhiyao LiJiansong Wang

Published in: Cancer biology & therapy (2024)

CircBIRC6 is highly expressed in prostate cancer samples. Knockdown of its expression inhibits cell proliferation, invasion, EMT and autophagy and promotes apoptosis. CircBIRC6/miRNA-574-5p/DNAJB1 is a molecular axis that regulates prostate cancer cells.

Keyphrases

prostate cancer
radical prostatectomy
cell proliferation
endoplasmic reticulum stress
oxidative stress
cell death
poor prognosis
epithelial mesenchymal transition
signaling pathway
cell cycle
binding protein
pi k akt