A Patient-Level Meta-Analysis of Intensive Glucose Control in Critically Ill Adults.
Derick AdigbliYang LiNaomi HammondRichard ChatoorAnthony G DevauxQiang LiLaurent BillotDjillali AnnaneYaseen ArabiFederico BilottaJulien BohéFrank Martin BrunkhorstAlexandre Biasi CavalcantiDeborah CookChristoph EngelDeborah Green-LaRocheWei HeWilliam HendersonCornelia HoedemaekersGaetano IapichinoPierre KalfonGisela de La RosaAfsaneh LahootiIain MackenzieSajeev MahendranChristian MélotImogen MitchellTuomas OksanenFederico PolliJean-Charles PreiserFrancisco Garcia SorianoRuan VlokLingcong WangYuan XuAnthony P DelaneyGian Luca Di TannaSimon FinferPublished in: NEJM evidence (2024)
Intensive glucose control was not associated with reduced mortality risk but increased the risk of severe hypoglycemia. We did not identify a subgroup of patients in whom intensive glucose control was beneficial. (Funded by the Australian National Health and Medical Research Council and others; PROSPERO number CRD42021278869.).