Molecular analysis of NPAS3 functional domains and variants.

Published in: BMC molecular biology (2018)

NPAS3 is a true transcription factor capable of regulating expression of target genes through their promoters by directly cooperating with ARNT. The tested human variants of NPAS3 require further characterization to identify their effects on NPAS3 expression and function in the individuals that carry them. These data enhance our understanding of the molecular function of NPAS3 and the mechanism by which it contributes to normal and abnormal neurodevelopment and neural function.

Keyphrases

poor prognosis
transcription factor
copy number
endothelial cells
binding protein
gene expression
dna binding
induced pluripotent stem cells