Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses.
Janos L KalmanTomoya YoshidaTill F M AndlauerEva C SchulteKristina AdorjanMartin AldaRaffaela ArdauJean-Michel AubryKatharina BroschMonika BuddeCaterina ChillottiPiotr M CzerskiRaymond J DePauloAndreas ForstnerFernando S GoesMaria Grigoroiu-SerbanescuPaul GrofDominik GrotegerdTim HahnMaria HeilbronnerRoland HaslerUrs HeilbronnerStefanie Heilmann-HeimbachPawel KapelskiTadafumi KatoMojtaba Oraki KohshourSusanne MeinertTina MellerIgor NenadićMarkus M NöthenTomas NovakNils OpelJoanna PawlakJulia-Katharina PfarrJames B PotashDaniela Reich-ErkelenzJonathan ReppleHélène Richard-LepourielMarcella RietschelKai G RingwaldGuy RouleauSabrina SchauppFanny SennerGiovanni SeverinoAlessio SquassinaFrederike SteinPavla StopkovaFabian StreitKatharina ThielFlorian Thomas-OdenthalGustavo TureckiJoanna Twarowska-HauserAlexandra WinterPeter P ZandiJohn R Kelsoenull nullPeter FalkaiUdo DannlowskiTilo KircherThomas G SchulzeSergi PapiolPublished in: European archives of psychiatry and clinical neuroscience (2022)
Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.
Keyphrases
- depressive symptoms
- mental health
- bipolar disorder
- end stage renal disease
- systematic review
- meta analyses
- ejection fraction
- newly diagnosed
- randomized controlled trial
- chronic kidney disease
- magnetic resonance
- peritoneal dialysis
- gene expression
- magnetic resonance imaging
- big data
- machine learning
- dna methylation
- mental illness
- neural network