Living systematic review and meta-analysis of plasma-concentrations of antipsychotic drugs in carriers and non-carriers of variant CYP450 genotypes: Living systematic review protocol.
Filip MilosavljevićStefan LeuchtPublished in: F1000Research (2024)
This systematic review will provide evidence-based results that are continuously updated with evidence as it emerges in the rapidly developing field of pharmacogenomics. These results may help psychiatrists in their decision-making, as clinicians are becoming increasingly aware of the patients' genetic data as testing becomes more widespread and cheaper. In addition, the results may serve as a scientific basis for the development of evidence-based pharmacogenomics algorithms for personalized dosing of antipsychotics to mitigate potentially harmful drug-gene interactions.
Keyphrases
- systematic review
- meta analyses
- end stage renal disease
- decision making
- genome wide
- ejection fraction
- randomized controlled trial
- newly diagnosed
- chronic kidney disease
- adverse drug
- prognostic factors
- peritoneal dialysis
- emergency department
- gene expression
- clinical decision support
- deep learning
- big data
- transcription factor