Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases.

Matthew TraylorRachel KnevelJing CuiJohn TaylorWestra Harm-JanPhilip G ConaghanAndrew P CopeCharles CurtisPaul EmeryStephen NewhouseHamel PatelSophia SteerPeter GregersenNancy A ShadickMichael E WeinblattAnnette Van Der Helm-van MilJennifer H BarrettAnn W MorganCathryn M LewisIan C Scott

Published in: PloS one (2019)

Our meta-analysis confirms the known association between the HLA-DRB1 shared epitope and RA radiological damage. The lack of replication of previously validated non-HLA markers highlights a requirement for further research to deliver clinically-useful prognostic genetic markers.

Keyphrases

systematic review
rheumatoid arthritis
case control
genome wide association
meta analyses
oxidative stress
genome wide
disease activity
ankylosing spondylitis
randomized controlled trial
gene expression
systemic lupus erythematosus
systemic sclerosis
monoclonal antibody