Trimethylamine N-oxide and incident atherosclerotic events in high-risk individuals with diabetes: an ACCORD trial post hoc analysis.

Andrea CardonaAaron O'BrienMatthew C BernierArpad SomogyiVicki H WysockiSuzanne SmartXin HeGiuseppe AmbrosioWilla Ann Hsueh Subha V Raman

Published in: BMJ open diabetes research & care (2019)

TMAO's prognostic value for incident ASCVD events may be blunted when applied to individuals with T2D with poor glycemic control and high baseline ASCVD risk. These results behoove further translational investigations of unique mechanisms of ASCVD risk in T2D.

Keyphrases

glycemic control
type diabetes
cardiovascular disease
blood glucose
clinical trial
weight loss
study protocol
insulin resistance
randomized controlled trial
phase iii
skeletal muscle
metabolic syndrome
open label