Fenofibrate up-regulated PPARα/PGC-1α signaling pathway, promoted mitochondrial β-oxidation, reduced oxidative stress damage and lipid accumulation of liver. PGC-1α overexpression enhanced mitochondrial biosynthesis and ATP production, and reduced HepG2 intracellular accumulation of lipids and oxidative stress.
Keyphrases
- oxidative stress
- signaling pathway
- skeletal muscle
- induced apoptosis
- insulin resistance
- pi k akt
- diabetic rats
- ischemia reperfusion injury
- dna damage
- transcription factor
- fatty acid
- epithelial mesenchymal transition
- cell proliferation
- hydrogen peroxide
- heat shock
- reactive oxygen species
- room temperature
- nitric oxide
- metabolic syndrome
- adipose tissue
- endoplasmic reticulum stress
- heat shock protein