Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors.

Marije NiemeijerWitold WięcekShuai FuSuzanna HuppelschotenPeter BouwmanAudrey BazeCéline ParmentierLysiane RichertRichard S PaulesFrederic Y BoisBob van de Water

Published in: Environmental health perspectives (2024)

-based prediction of adverse responses, in particular hepatotoxicity. https://doi.org/10.1289/EHP11891.

Keyphrases

high throughput
single cell
endothelial cells
high resolution
induced pluripotent stem cells
pluripotent stem cells
drug induced
emergency department
high density
mass spectrometry