Epiregulin increases stemness-associated genes expression and promotes chemoresistance of non-small cell lung cancer via ERK signaling.
Yujia ZhangFengjun QiuTingjie YeSau Har LeeJiatuo XuLingyan JiaRui ZengXiaoling WangXudong HuXiaofeng YanHua LiYanlin LuXiaoling WangRilei JiangWei XuPublished in: Stem cell research & therapy (2022)
These findings revealed 6 resistance genes signature and proved that EREG/ErbB regulated the stemness to maintain chemoresistance of NSCLC via ERK signaling. Therefore, targeting EREG/ErbB might significantly and effectively resolve the chemoresistance issue.
Keyphrases
- cancer stem cells
- signaling pathway
- stem cells
- epithelial mesenchymal transition
- genome wide
- cell proliferation
- tyrosine kinase
- pi k akt
- small cell lung cancer
- poor prognosis
- bioinformatics analysis
- genome wide identification
- cancer therapy
- single cell
- advanced non small cell lung cancer
- binding protein
- gene expression
- drug delivery