Polygenic Risk Scores have high diagnostic capacity in ankylosing spondylitis.
Zhixiu LiXin WuPaul J LeoErika De GuzmanNurullah AkkocMaxime BrebanGary John MacfarlaneMahdi MahmoudiHelena Marzo-OrtegaLisa K AndersonLawrie WheelerChung-Tei ChouAndrew A HarrisonSimon M StebbingsGareth T JonesSo-Young BangGeng WangAhmadreza JamshidiElham FarhadiJing SongLi LinMengmeng LiJames Cheng Chung WeiNicholas G MartinMargaret J WrightMin Jae LeeYuqin WangJian ZhanJin-San ZhangXiaobing WangZi-Bing JinMichael H WeismanLianne S GenslerMichael M WardMohammad Hossein RahbarLaura DiekmanTae Hwan KimJohn D ReveilleBryan Paul WordsworthHuji XuMatthew A Brownnull nullPublished in: Annals of the rheumatic diseases (2021)
PRS have higher discriminatory capacity for AS than CRP, sacroiliac MRI or HLA-B27 status alone. For optimal performance, PRS should be developed for use in the specific ethnic groups to which they are to be applied.