Dynamic changes of CSF sPDGFRβ during ageing and AD progression and associations with CSF ATN biomarkers.

Jun WangDong-Yu FanHui-Yun LiChen-Yang HeYing-Ying ShenGui-Hua ZengDong-Wan ChenXu YiYa-Hui MaJin-Tai YuYan-Jiang Wang

Published in: Molecular neurodegeneration (2022)

Our results suggest that pericyte injury contributes to AD progression in the early stage in an Aβ-independent pathway. Recovery of pericyte function would be a target for prevention and early intervention of AD.

Keyphrases

early stage
blood brain barrier
randomized controlled trial
cerebrospinal fluid
squamous cell carcinoma
sentinel lymph node
radiation therapy