Isolation of Lobane and Prenyleudesmane Diterpenoids from the Soft Coral Lobophytum varium.
Chuan-Hsiang ChangAtallah F AhmedTian-Sheng YangYou-Cheng LinChiung-Yao HuangTsong-Long HwangJyh-Horng SheuPublished in: Marine drugs (2020)
Further chemical investigation of the EtOAc extract of the soft coral Lobophytum varium resulted in the discovery of eleven new diterpenoids lobovarols F-P (1-11) of lobane- and prenyleudesmane-types, along with two known metabolites (12 and 13). The structures of the new metabolites were established by spectroscopic analyses, including 2D NMR experiments. The absolute configuration of 1 was determined using Mosher's method. The complete assignment of 1H and 13C NMR spectroscopic data of 12 and 13 and the identification of pyran-derived moieties in the prenyleudesmanes were reported for the first time. Anti-inflammatory activities of the isolated compounds in suppressing elastase release and superoxide anion generation in human neutrophils were disclosed for 1, 2, 4, 12, and 13. A stereospecific biosynthesis for lobanes and prenyleudesmanes from the related prenylgermacranes could explain the coexistence of lobanes and prenylgermacranes in L. varium.
Keyphrases
- anti inflammatory
- high resolution
- molecular docking
- ms ms
- magnetic resonance
- solid state
- endothelial cells
- small molecule
- induced pluripotent stem cells
- signaling pathway
- oxidative stress
- hydrogen peroxide
- high throughput
- ionic liquid
- big data
- pluripotent stem cells
- molecular dynamics simulations
- cell wall
- deep learning
- data analysis
- drug induced