Cytotoxic Heptaketides from the Endolichenic Fungus Ulospora bilgramii.
Fei XieXiao-Yi LuanYun GaoKe XuHong-Xiang LouPublished in: Journal of natural products (2020)
Eleven new metabolites including nine heptaketides, ulosporin A-G (1a-7b), one diphenyl compound, ulophenol (8), and one spirobisnaphthalene, palmarumycin P5 (9), were isolated from the endolichenic fungus Ulospora bilgramii, which inhabits the lichen Umbilicaria sp. The structures of these compounds were elucidated based on comprehensive analysis of their spectroscopic, electronic circular dichroism (ECD), and single-crystal X-ray diffraction data. Ulosporin G (7) inhibited the growth of the human cancer cell lines A549, MCF-7, and KB with IC50 values of 1.3, 1.3, and 3.0 μM, respectively. Additionally, it induced A549 cell apoptosis through G0/G1 cell cycle arrest caused by DNA damage.
Keyphrases
- cell cycle arrest
- dna damage
- cell death
- endothelial cells
- high glucose
- pi k akt
- high resolution
- papillary thyroid
- oxidative stress
- cell proliferation
- diabetic rats
- ms ms
- molecular docking
- squamous cell
- electron microscopy
- electronic health record
- breast cancer cells
- induced pluripotent stem cells
- pluripotent stem cells
- drug induced
- signaling pathway
- big data
- computed tomography
- squamous cell carcinoma
- magnetic resonance imaging
- dual energy
- machine learning
- lymph node metastasis
- data analysis
- crystal structure
- solid state
- deep learning
- contrast enhanced