Characterising the autoantibody repertoire in systemic sclerosis following myeloablative haematopoietic stem cell transplantation.
Burcu AyogluMichele DonatoDaniel E FurstLeslie J CroffordEllen GoldmuntzLynette Keyes-ElsteinJudith A JamesSusan MacwanaMaureen D MayesPeter McSweeneyRichard A NashKeith M SullivanBeverly WelchAshley PinckneyRong MaoLorinda ChungPurvesh KhatriPaul J UtzPublished in: Annals of the rheumatic diseases (2023)
Our results suggest that HSCT favourably alters the autoantibody repertoire, which remains virtually unchanged in CTX-treated patients. Although antibodies recognising secreted proteins are generally thought to be pathogenic, our results suggest a subset could potentially modulate HSCT in scleroderma.