Short-Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties.
Jacob Marthinsen SeefeldtCasper HomiliusJakob HansenThomas Ravn LassenNichlas Riise JespersenRebekka Vibjerg JensenDonna M B BoedtkjerHans Erik BotkerBent Roni Ranghøj NielsenPublished in: Journal of the American Heart Association (2024)
We conclude that butyrate elevates cardiac output through mechanisms involving increased cardiac contractility and vasorelaxation. This effect of butyrate was not associated with adverse myocardial injury in damaged hearts exposed to ischemia and reperfusion.