Sensitivity Assessment of Wilms Tumor Gene (WT1) Expression in Glioblastoma using qPCR and Immunohistochemistry and its Association with IDH1 Mutation and Recurrence Interval.

Maher Kurdi Nadeem Shafique Butt Saleh Salem Baeesa Abudukadeer Kuerban Yazid Maghrabi Anas BardeesiRothaina SaeediBadrah Saeed Alghamdi Ahmed I Lary Fawaz MohamedSahar Hakamy

Published in: Biologics : targets & therapy (2021)

Parallel testing for WT1 expression using IHC and qPCR is not reliable. However, IHC provides more accurate results. Moreover, IDH1mutant glioblastomas with WT1 overexpression are associated with late RFI particularly if temozolomide with additional chemotherapies are used.

Keyphrases

poor prognosis
wild type
low grade
cell proliferation
long non coding rna
copy number
genome wide
transcription factor
high resolution
gene expression
mass spectrometry