ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells.

Monika A Jakubowska Martijn Kerkhofs Claudio Martines Dimitar G Efremov Julia V Gerasimenko Oleg V Gerasimenko Ole H Petersen Geert Bultynck Tim Vervliet Pawel E Ferdek

Published in: British journal of pharmacology (2018)

This article is part of a themed section on Mitochondrial Pharmacology: Featured Mechanisms and Approaches for Therapy Translation. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.22/issuetoc.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
benign prostatic hyperplasia
lower urinary tract symptoms
endoplasmic reticulum stress
cell death
stem cells