Geert Bultynck

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 39

Top Venues

KU Leuven

KU Leuven (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

KU Leuven Oct 01 2020

Belgium

Full Professor :: Cellular and Molecular Medicine

KU Leuven Oct 01 2016

Belgium

Professor :: Cellular and Molecular Life Sciences

KU Leuven

Belgium

Associate Professor :: Cellular and Molecular Medicine

KU Leuven

Belgium

Assistant Professor :: Molecular and Cellular Biology

KU Leuven

Belgium

post-doctoral researcher (Research Foundation - Flanders; FWO) :: Physiology

Stanford University

United States

post-doctoral researcher (FWO fellow) :: Biological Sciences

Stanford Univeristy

United States

post-doctoral researcher (BAEF fellow) :: Biological Sciences

KU Leuven

Belgium

post-doctoral researcher (PDM) :: Physology

Education History

KU Leuven

Belgium

PHD :: Physiology

KU Leuven

Belgium

MSC :: Biochemistry

KU Leuven Sep 21 1993 - Jul 03 1995

Belgium

BSC :: Chemistry

Publications

Femke Speelman-Rooms, Maarten Vanmunster, Aled Coughlan, Macarena Hinrichs, Ilaria Pontisso, Solene Barbeau, Thibaud Parpaite, Geert Bultynck, Malene Brohus
10th European Calcium Society symposium: The Ca2+-signaling toolkit in cell function, health and disease. Biology open 13 (4) (2024)
Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam Ann Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Loncke, Tim Vervliet, Ting-Fen Tsai, Geert Bultynck, Vladimir Veksler, Allen Kaasik
ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome. Nature communications 15 (1) (2024)
Femke Speelman-Rooms, Maarten Vanmunster, Aled Coughlan, Macarena Hinrichs, Ilaria Pontisso, Solene Barbeau, Thibaud Parpaite, Geert Bultynck, Malene Brohus
10th European Calcium Society symposium: The Ca2+-signaling toolkit in cell function, health and disease. Biology open 13 (4) (2024)
Malene Brohus, Martin D Bootman, Geert Bultynck
Sustainability in a broad sense: An essential aspect of scientific conferences. BioEssays : news and reviews in molecular, cellular and developmental biology 46 (7) (2024)
Rudy Gadet, Lea Jabbour, Trang Thi Minh Nguyen, Olivier Lohez, Ivan Mikaelian, Philippe Gonzalo, Tomas Luyten, Mounira Chalabi-Dchar, Anne Wierinckx, Olivier Marcillat, Geert Bultynck, Ruth Rimokh, Nikolay Popgeorgiev, Germain Gillet
The endoplasmic reticulum pool of Bcl-xL prevents cell death through IP3R-dependent calcium release. Cell death discovery 10 (1) (2024)
Femke Speelman-Rooms, Maarten Vanmunster, Aled Coughlan, Macarena Hinrichs, Ilaria Pontisso, Solene Barbeau, Thibaud Parpaite, Geert Bultynck, Malene Brohus
10th European Calcium Society symposium: The Ca2+-signaling toolkit in cell function, health and disease. Biology open 13 (4) (2024)
Malene Brohus, Martin D Bootman, Geert Bultynck
Sustainability in a broad sense: An essential aspect of scientific conferences. BioEssays : news and reviews in molecular, cellular and developmental biology (2024)
Malene Brohus, Martin D Bootman, Geert Bultynck
Sustainability in a broad sense: An essential aspect of scientific conferences. BioEssays : news and reviews in molecular, cellular and developmental biology 46 (7) (2024)
Rudy Gadet, Lea Jabbour, Trang Thi Minh Nguyen, Olivier Lohez, Ivan Mikaelian, Philippe Gonzalo, Tomas Luyten, Mounira Chalabi-Dchar, Anne Wierinckx, Olivier Marcillat, Geert Bultynck, Ruth Rimokh, Nikolay Popgeorgiev, Germain Gillet
The endoplasmic reticulum pool of Bcl-xL prevents cell death through IP3R-dependent calcium release. Cell death discovery 10 (1) (2024)
Femke Speelman-Rooms, Maarten Vanmunster, Aled Coughlan, Macarena Hinrichs, Ilaria Pontisso, Solene Barbeau, Thibaud Parpaite, Geert Bultynck, Malene Brohus
10th European Calcium Society symposium: The Ca2+-signaling toolkit in cell function, health and disease. Biology open 13 (4) (2024)
Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam Ann Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Loncke, Tim Vervliet, Ting-Fen Tsai, Geert Bultynck, Vladimir Veksler, Allen Kaasik
ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome. Nature communications 15 (1) (2024)
Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam Ann Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Loncke, Tim Vervliet, Ting-Fen Tsai, Geert Bultynck, Vladimir Veksler, Allen Kaasik
ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome. Nature communications 15 (1) (2024)
Rudy Gadet, Lea Jabbour, Trang Thi Minh Nguyen, Olivier Lohez, Ivan Mikaelian, Philippe Gonzalo, Tomas Luyten, Mounira Chalabi-Dchar, Anne Wierinckx, Olivier Marcillat, Geert Bultynck, Ruth Rimokh, Nikolay Popgeorgiev, Germain Gillet
The endoplasmic reticulum pool of Bcl-xL prevents cell death through IP3R-dependent calcium release. Cell death discovery 10 (1) (2024)
Femke Speelman-Rooms, Maarten Vanmunster, Aled Coughlan, Macarena Hinrichs, Ilaria Pontisso, Solene Barbeau, Thibaud Parpaite, Geert Bultynck, Malene Brohus
10th European Calcium Society symposium: The Ca2+-signaling toolkit in cell function, health and disease. Biology open 13 (4) (2024)
Flore Sneyers, Martijn Kerkhofs, Femke Speelman-Rooms, Kirsten Welkenhuyzen, Rita La Rovere, Ahmed Shemy, Arnout Voet, Guy Eelen, Mieke Dewerchin, Stephen W G Tait, Bart Ghesquière, Martin D Bootman, Geert Bultynck
Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells. Cell death & disease 14 (9) (2023)
Elżbieta Kania, Jaclyn S Long, David G McEwan, Kirsten Welkenhuyzen, Rita La Rovere, Tomas Luyten, John Halpin, Evy Lobbestael, Veerle Baekelandt, Geert Bultynck, Kevin M Ryan, Jan B Parys
LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner. Cell death & disease 14 (7) (2023)
Fernanda O Lemos, Ian de Ridder, Martin D Bootman, Geert Bultynck, Jan B Parys
The Complex Effects of PKM2 and PKM2:IP 3 R Disruption on Intracellular Ca 2+ Handling and Cellular Functions. Cells 12 (21) (2023)
Peter Vandenabeele, Geert Bultynck, Savvas N Savvides
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways. Nature reviews. Molecular cell biology (2022)
Li Zhang, Felicia Dietsche, Bruno Seitaj, Liliana Rojas-Charry, Nadina Latchman, Dhanendra Tomar, Rob C I Wüst, Alexander Nickel, Katrin B M Frauenknecht, Benedikt Schoser, Sven Schumann, Michael J Schmeisser, Johannes Vom Berg, Thorsten Buch, Stefanie Finger, Philip Wenzel, Christoph Maack, John W Elrod, Jan B Parys, Geert Bultynck, Axel Methner
TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy. Life science alliance 5 (10) (2022)
Peter Vandenabeele, Geert Bultynck, Savvas N Savvides
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways. Nature reviews. Molecular cell biology (2022)
George Shapovalov, Abigaël Ritaine, Nadege Charlene Essonghe, Ian de Ridder, Hristina Ivanova, Spyridoula Karamanou, Anastassios Economou, Geert Bultynck, Roman Skryma, Natalia Prevarskaya
Allosteric cross-talk between the hydrophobic cleft and the BH4 domain of Bcl-2 in control of inositol 1,4,5-trisphosphate receptor activity. Exploration of targeted anti-tumor therapy 3 (3) (2022)
Manon Callens, Jens Loncke, Geert Bultynck
Dysregulated Ca 2+ Homeostasis as a Central Theme in Neurodegeneration: Lessons from Alzheimer's Disease and Wolfram Syndrome. Cells 11 (12) (2022)
Peter Vandenabeele, Geert Bultynck, Savvas N Savvides
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways. Nature reviews. Molecular cell biology (2022)
Jens Loncke, Tim Vervliet, Jan B Parys, Allen Kaasik, Geert Bultynck
Uniting the divergent Wolfram syndrome-linked proteins WFS1 and CISD2 as modulators of Ca2+ signaling. Science signaling 14 (702) (2021)
Nicolas Rosa, Hristina Ivanova, Larry E Wagner, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos N Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada, Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W Andrews, Jan B Parys, David I Yule, Geert Bultynck
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis. Cell death and differentiation (2021)
Jenny Sprooten, Pieter De Wijngaert, Isaure Vanmeerbeerk, Shaun Martin, Peter Vangheluwe, Susan Schlenner, Dmitri V Krysko, Jan B Parys, Geert Bultynck, Peter Vandenabeele, Abhishek Dinkarnath Garg
Necroptosis in Immuno-Oncology and Cancer Immunotherapy. Cells 9 (8) (2020)
Besa Emini Veseli, Paola Perrotta, Pieter Van Wielendaele, Anne-Marie Lambeir, Anahita Abdali, Stefano Bellosta, Giovanni Monaco, Geert Bultynck, Wim Martinet, Guido R Y De Meyer
Small molecule 3PO inhibits glycolysis but does not bind to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3). FEBS letters 594 (18) (2020)
Bruno Seitaj, Felicia Maull, Li Zhang, Verena Wüllner, Christina Wolf, Philipp Schippers, Rita La Rovere, Ute Distler, Stefan Tenzer, Jan B Parys, Geert Bultynck, Axel Methner
Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery. Cells 9 (10) (2020)
Martijn Kerkhofs, Tamara Vervloessem, Kinga B Stopa, Victoria M Smith, Meike Vogler, Geert Bultynck
DLBCL Cells with Acquired Resistance to Venetoclax Are Not Sensitized to BIRD-2 But Can Be Resensitized to Venetoclax through Bcl-XL Inhibition. Biomolecules 10 (7) (2020)
Tamara Vervloessem, Binu K Sasi, Elena Xerxa, Spyridoula Karamanou, Justin Kale, Rita M La Rovere, Supriya Chakraborty, Flore Sneyers, Meike Vogler, Anastassios Economou, Luca Laurenti, David William Andrews, Dimitar G Efremov, Geert Bultynck
BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models. Cell death & disease 11 (9) (2020)
Delphine Hoorelbeke, Elke Decrock, Maarten A J De Smet, Marijke De Bock, Benedicte Descamps, Valérie Van Haver, Tinneke Delvaeye, Dmitri V Krysko, Christian Vanhove, Geert Bultynck, Luc Leybaert
Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells. Cell death & disease 11 (3) (2020)
Nefele Giarratana, Filippo Conti, Rita La Rovere, Rik Gijsbers, Paolo Carai, Robin Duelen, Tim Vervliet, Geert Bultynck, Flavio Ronzoni, Roberto Piciotti, Domiziana Costamagna, Rosa Grazia Bellomo, Ivana Barravecchia, Debora Angeloni, Yvan Torrente, Maurilio Sampaolesi
MICAL2 is essential for myogenic lineage commitment. Cell death & disease 11 (8) (2020)
Hristina Ivanova, Larry E Wagner, Akihiko Tanimura, Elien Vandermarliere, Tomas Luyten, Kirsten Welkenhuyzen, Kamil J Alzayady, Liwei Wang, Kozo Hamada, Katsuhiko Mikoshiba, Humbert De Smedt, Lennart Martens, David I Yule, Jan B Parys, Geert Bultynck
Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output. Cellular and molecular life sciences : CMLS 76 (19) (2019)
Gemma Roest, Evelien Hesemans, Kirsten Welkenhuyzen, Tomas Luyten, Nikolai Engedal, Geert Bultynck, Jan B Parys
The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner. Cells 7 (12) (2018)
Mart Bittremieux, Rita M La Rovere, Marleen Schuermans, Tomas Luyten, Katsuhiko Mikoshiba, Peter Vangheluwe, Jan B Parys, Geert Bultynck
Extracellular and ER-stored Ca2+ contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells. Cell death discovery 4 (2018)
Mart Bittremieux, Rita M La Rovere, Haidar Akl, Claudio Martines, Kirsten Welkenhuyzen, Kathia Dubron, Myriam Baes, Ann Janssens, Peter Vandenberghe, Luca Laurenti, Katja Rietdorf, Giampaolo Morciano, Paolo Pinton, Katsuhiko Mikoshiba, Martin D Bootman, Dimitar G Efremov, Humbert De Smedt, Jan B Parys, Geert Bultynck
Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2. Cell death and differentiation 26 (3) (2018)
Martijn Kerkhofs, Mart Bittremieux, Giampaolo Morciano, Carlotta Giorgi, Paolo Pinton, Jan B Parys, Geert Bultynck
Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes. Cell death & disease 9 (3) (2018)
Monika A Jakubowska, Martijn Kerkhofs, Claudio Martines, Dimitar G Efremov, Julia V Gerasimenko, Oleg V Gerasimenko, Ole H Petersen, Geert Bultynck, Tim Vervliet, Pawel E Ferdek
ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells. British journal of pharmacology 176 (22) (2018)
Jegan Iyyathurai, Nan Wang, Catheleyne D'hondt, Jean X Jiang, Luc Leybaert, Geert Bultynck
The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity. Cellular and molecular life sciences : CMLS 75 (11) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Geert Bultynck