Efficacy and Safety of Ibuprofen Plus Paracetamol in a Fixed-Dose Combination for Acute Postoperative Pain in Adults: Meta-Analysis and a Trial Sequential Analysis.
Dina AbushanabDaoud Al-BadriyehPublished in: CNS drugs (2021)
The ibuprofen plus paracetamol FDC is conclusively an effective analgesic against placebo in acute postoperative, moderate to severe pain in adults. It is also superiorly well tolerated, including at the higher dose of 292.5-400 mg ibuprofen/975-1000 mg paracetamol; however, safety outcomes were inconclusive. Future studies need to confirm the safety of FDC and its benefits against other marketed analgesics in postoperative pain.
Keyphrases
- postoperative pain
- liver failure
- systematic review
- respiratory failure
- drug induced
- case control
- phase iii
- aortic dissection
- anti inflammatory drugs
- neuropathic pain
- early onset
- study protocol
- chronic pain
- type diabetes
- randomized controlled trial
- phase ii
- spinal cord injury
- weight loss
- metabolic syndrome
- intensive care unit
- extracorporeal membrane oxygenation
- anti inflammatory
- open label
- acute respiratory distress syndrome