Dietary wheat amylase trypsin inhibitors exacerbate CNS inflammation in experimental multiple sclerosis.
Victor F ZevallosNir YogevJudith HauptmannAlexei NikolaevGeethanjali PickertValeska HeibNicola FittlerSebastian StevenFelix LuessiManjusha NeerukondaClaudia JanoschkaAnn-Marie TobinskiLuisa KlotzEsther Von StebutVictor F ZevallosPublished in: Gut (2023)
Dietary wheat ATI activate murine and human myeloid cells. The amount of ATI present in an average human wheat-based diet caused mild intestinal inflammation, which was propagated to extraintestinal sites, leading to exacerbation of CNS inflammation and worsening of clinical symptoms in EAE. These results support the importance of the gut-brain axis in inflammatory CNS disease.
Keyphrases
- oxidative stress
- multiple sclerosis
- endothelial cells
- induced apoptosis
- blood brain barrier
- induced pluripotent stem cells
- chronic obstructive pulmonary disease
- pluripotent stem cells
- white matter
- physical activity
- acute myeloid leukemia
- weight loss
- cell proliferation
- resting state
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome