Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.
Akiyoshi NakayamaMasahiro NakatochiYusuke KawamuraKen YamamotoHirofumi NakaokaSeiko ShimizuToshihide HigashinoTeruhide KoyamaAsahi HishidaKiyonori KurikiMiki WatanabeToru ShimizuKeiko OoyamaHiroshi OoyamaMitsuo NagaseYuji HidakaDaisuke MatsuiTakashi TamuraTakeshi NishiyamaChisato ShimanoeSakurako Katsuura-KamanoNaoyuki TakashimaYuya ShiraiMakoto KawaguchiMikiya TakaoRyo SugiyamaYuzo TakadaTakahiro NakamuraHiroshi NakashimaMasashi TsunodaInaho DanjohAtsushi HozawaKazuyoshi HosomichiYu ToyodaYu KubotaTappei TakadaHiroshi SuzukiBlanka StiburkovaTanya J MajorTony R MerrimanNagato KuriyamaHaruo MikamiToshiro TakezakiKeitaro MatsuoSadao SuzukiTatsuo HosoyaYoichiro KamataniMichiaki KuboKimiyoshi IchidaKenji WakaiIturo InoueYukinori OkadaNariyoshi ShinomiyaHirotaka Matsuonull nullPublished in: Annals of the rheumatic diseases (2020)
Our findings on subtype GWAS meta-analyses and selection pressure analysis of gout will assist elucidation of the subtype-dependent molecular targets and evolutionary involvement among genotype, phenotype and subtype-specific tailor-made medicine/prevention of gout and hyperuricaemia.