Quantitative analysis of MGMT promoter methylation in glioblastoma suggests nonlinear prognostic effect.

David GibsonAkshay RaviEduardo RodriguezSusan ChangNancy Oberheim BushJennie W Taylor Jennifer L ClarkeDavid SolomonAaron SchefflerJohn WitteHannah LambingHideho OkadaMitchel BergerFarid ChehabNicholas A Butowski

Published in: Neuro-oncology advances (2023)

and underlines the clinical importance of determining its prognostic utility. Potential limitations include censoring, sample size, and extraneous mutations.

Keyphrases

dna methylation
gene expression
genome wide
human health
risk assessment
climate change