Inference of Cellular Immune Environments in Sputum and Peripheral Blood Associated with Acute Exacerbations of COPD.

Katy C Norman Christine M FreemanNeha S BidthanapallyMeiLan K HanFernando J MartinezJeffrey L Curtis Kelly B Arnold

Published in: Cellular and molecular bioengineering (2019)

Our results supported a new hypothesis that AE-COPD is driven by immune cell trafficking into the lung, which requires expression of cell adhesion molecules and raised levels of innate immune cells in blood, with parallel upregulated expression of specific chemokines in pulmonary tissue. Overall, this work serves as a proof-of-concept for using data-driven modeling approaches to generate new insights into cellular processes involved in complex pulmonary diseases.

Keyphrases

chronic obstructive pulmonary disease
poor prognosis
cell adhesion
peripheral blood
cystic fibrosis
pulmonary hypertension
lung function
immune response
liver failure
mycobacterium tuberculosis
binding protein
single cell
long non coding rna
respiratory failure
aortic dissection