The differential expression of long interspersed nuclear elements-1 as a marker for hypomethylation in Merkel cell carcinoma.
Yuko KuriyamaAkira ShimizuJain KimMasahito YasudaSei-Ichiro MotegiPublished in: Clinical and experimental dermatology (2022)
The protein long interspersed nuclear elements-1 (LINE-1) serves as a useful surrogate marker of global methylation but little is known for Merkel cell carcinoma. LINE-1 expression was found only in Merkel cell polyomavirus (MCPyV)-positive Merkel cell carcinomas but not in MCPyV-negative Merkel cell carcinomas, suggesting that epigenetic dysregulation may be associated with MCPyV expression.